Endocrine Abstracts

Introduction: Intronic BclI polymorphism of glucocorticoid receptor (GR) gene and adrenal adenomas of incidental discovery are frequently associated with metabolic syndrome. We studied in these patients metabolic and hormonal parameters, the sequence alteration in BclI polymorphism of the GR gene from constitutive DNA and the expression of Hsp70 within the tumor and in tissue adjacently to tumor.Patients and methods: We assessed 114 healthy...

A 34-year-old woman was initially presented with clinical signs of Cushing’s syndrome (CS). On endocrinological examination, a diagnosis of ACTH dependent CS was established (serum cortisol: 08.00 h: 1245 nmol/l; 24.00 h: 275; plasma ACTH concentration 104 ng/l; inadequate cortisol suppresion on LDDST (787) and suppresion to 318 following HDDST). A magnetic resonance imaging (MRI) confirmed a microadenoma in the left part of the pituitary. Ultrasound examination confirmed...

Background: Mutational screening of the MEN1 gene has been recommended for patients who fulfill clinical criteria for familial or sporadic MEN1 and those suspicious or atypical of MEN1.Patients and methods: Eighteen apparently unrelated individuals (6 males; 12 females, age range 16–71) with clinical manifestations of MEN1 were analised. In addition, we evaluated 7 relatives. Genomic DNA from peripheral blood leucocytes was extracted using st...

Aim of this study was to investigate head to head ACTH and cortisol responses to DDAVP and ghrelin in patients with CD. Study was approved by the local ethics committee and informed consent obtained. Nine patients with CD were submitted to ghrelin 1 μg/kg and DDAVP 10 μg bolus iv administration on two separate occasions. Blood was sampled at 0.15, 30, 45, 60, 90 min. for ACTH (ELISA) and cortisol (RIA, Cis, Bio International, France) measurements.<p class="abstex...

Introduction: Hypothalamo-pituitary-adrenal (HPA) axis dysregulation could be a link between polycystic ovary syndrome (PCOS) and cardiometabolic and psychological complications associated with disease.Methods: We analyzed 50 women with PCOS according to ESHRE/ASRM criteria [age 28.66±5.61, body mass index (BMI) 21.94±3.38 kg/m2] and 50 BMI- and age-matched healthy women (control group, CG), (age 28.66±5.63, BMI 22.09±3.70 ...

Interindividual variations in tissue sensitivity to glucocorticoids have been partly attributed to polymorphisms in the glucocorticoid receptor (GR) gene. The aim of this study was to investigate the prevalence of subclinical hypercortisolism (SH) in women with adrenal incidentaloma (AI), and whether BclI variant of the GR gene may contribute to metabolic abnormalities frequently present in these patients. We evaluated 106 women with AI. Anthropometric characteristics...

Germline ARMC5 mutations have been described as the most frequent genetic abnormality found in patients diagnosed with primary bilateral macronodular adrenal hyperplasia (PBMAH). PBMAH is a rare etiology of Cushing’s syndrome. This gene has been proposed to acts as a tumor-suppressor gene. A 36-years old female presented to us with clinical signs of hypercortisolism. ACTH dependent Cushing’s syndrome was confirmed soon after. Pituitary magnetic resonance imaging (MRI...

Introduction: Oligomenorrhoea have negative impact on bone mineral density (BMD). The aim of this study was to analyze BMD in oligomenorrhoeic women with polycystic ovary syndrome (PCOS), and healthy controls with regular menstrual cycles.Methods: We analyzed 29 women with PCOS diagnosed using ESHRE/ASRM criteria (age: 23.6±4.7 years, BMI: 24.9±6.1 kg/m2) and 22 healthy BMI-matched controls (HC) (age 31.6±6.3 years, BMI 24.9&#17...

Introduction: Hyperandrogenism (HA) is frequent but not universal characteristic in women with polycistic ovary syndrome (PCOS). According to the ESHRE/ASRM definition, hyperandrogenism criterion could be clinical (hirsutism) and/or biochemical (hiperandrogenemia). The aim of this study was to analyze metabolic and hormonal characteristics among women with PCOS with different forms of hyperandrogenism.Methods: We analyzed 458 women with PCOS diagnosed us...

Introduction: Women with polycystic ovary syndrome (PCOS) often have other comorbidities and one of them is Hashimoto thyroiditis (HT). The aim of the sudy was to analyze metabolic and hormonal status among women with PCOS, with and without HT.Methods: We analyzed 167 women with PCOS diagnosed using ESHRE/ASRM criteria divided on PCOS with HT (PCOSwithHT, N=27, age: 25.8±5.2 years, BMI: 28.5±7.3 kg/m2) and without...